May 20 Presentation
Questions & Answers on "Long-term" COVID 19
Included below, a video of my PowerPoint presentation from May 20, 2022.
Embedded below on this page, the link to this video is https://youtu.be/fie9gImmHTY
which can be freely shared. Or click here to open this link on Youtube.
The description for this video:
"A presentation by William O'Neill, MD of his answers, with support for these from the relevant professional literature, to questions people asked about "long-term" COVID-19 (or PASC if you prefer). The goal is to inform, and no sales pitch is included. Relevant data leading to this, can be found at LTCOVID.com. Present work continues at StudyLTCOVID.com. First presented online on May 20, 2022."
Have a look!
May 20 Q & A: Round up the usual suspects
StudyLTCOVID.com
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"Long-term" COVID-19 may still be thought of as a new illness by many, caused by a "novel" coronavirus, though its existence can now be measured in years.
Clearly, it is not the first human illness studied. But approximately 100 articles concerning this viral illness are being published each day! The format for studying an illness was developed in Medicine over the centuries, but continues to evolve.
Such formats for presenting and learning about an illness will vary from infectious diseases to cancers, among others illnesses, but will nevertheless if successful find commonality.
And as we ponder Questions about "Long-term" COVID-19, perhaps we should
begin with "round up the usual suspects." (a phrase spoken by the character "Captain Reynaud" in the final scene of the movie Casablanca).
What are the 'usual suspects' or components that recur in the description of any illness?
Before trying to first formulate then share our answers with others, what might the context for such a Question & Answer session for this viral infectious disease and its "long-term" effects look like?
Perhaps this ...
(Suggestion: click the little box on the lower right to watch full screen).
Of course, formulating answers to questions about COVID-19 and "long-term" COVID, supposes keeping up with the literature so answers are accurate.
Not an easy feat, as this Science article informs.
"By one estimate, the COVID-19 literature published since January has reached more than 23,000 papers and is doubling every 20 days—among the biggest explosions of scientific literature ever.
Given that volume, "People don't have time to read through entire articles and figure out what is the value added and the bottom line, and what are the limitations," says Kate Grabowski, an infectious disease epidemiologist at Johns Hopkins University's (JHU's) Bloomberg School of Public Health who is leading an effort to create a curated set of pandemic papers."
Yet an overall sense of the characteristics of this illness may still be grasped and shared with others.
Perhaps surprising as a source of information for the public, the U.S. Department of Homeland Security lists COVID-19 as a threat to that security. It's DHS Science and Technology summary for defining that threat is quite complete, and perhaps most useful, it presents what is known, and also what is still to be learned. The Master Question List for COVID-19, a Monthly Report was last updated here on 11 January, 2022.
Here from that list is a one page summary on "long-term" COVID-19, (with our highlights):
Here below ia another resource that appeared more recently, but takes us away just a bit, from the "long-term" variety of the illness. Still a good source of information to share about the acute illness.
"CombatCOVID.hhs.gov is a one-stop location for the latest on preventing and treating COVID-19. The website offers resources for the public, healthcare providers, and public health professionals. You can also learn about clinical trials for COVID-19 prevention and treatments, and options for monoclonal antibody treatment. Visit Combat COVID to learn how you can help us all fight COVID-19."
Again, the information presented at that government site is quite centered on treatments for COVID-19, and less on defining the entity with is "long-term" COVID-19.
In light of these huge collections of information, our Question & Answer session on May 20 (2022) will of necessity be less complete and certainly not exhaustive. (Perhaps it should be a continuous week-long Podcast?)
Nevertheless, if the public who attends still has questions about "long-term" COVID-19, they merit being aired and answered. I think that just defined our goal or mission statement forthis presentation, May 20. (Times still to be arranged and updated here).
Questions for May 20 Presentation - Bibliography
StudyLTCOVID.com
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Depending on when you visited, the following may still be incomplete.
For those who use Zotero, information has also been shared via
Group Name: "Long COVID - May 20"
A free version of Zotero is available for download at this link.
Question numbering below serves only to facilitate sorting in our Bibliography, using Zotero.
Specific Questions that were asked, will be referred to here as well. To get a feel for all of that, just have a look below ...
Bibliography
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Overview or Summary data for "long-term" COVID (LTC)
2. Susceptibility to or Risk Factors for LTC
2a. Hypertension & Diabetes
2b. Down's Syndrome
2c. Nutrition and LTC susceptibility
2d. Genetic susceptibility
2e. Female predominance
2f. Acute findings predicting LTC
2g. BAME and Acute COVID
2g1. BAME & Long COVID (LTC)
3. Pediatrics and LTC
4. (Reserved Space)
5. Matching LTC to other illnesses
6. Therapeutic Approach
6a. Barrier Measures (Prevention)
Wang, X.; Pan, Y.; Zhang, D.; Chen, L.; Jia, L.; Li, X.; Yang, P.; Wang, Q.; Macintyre, C. R., Basic epidemiological parameter values from data of real-world in mega-cities: the characteristics of COVID-19 in Beijing, China. BMC Infectious Diseases 2020, 20 (1), 526. https://doi.org/10.1186/s12879-020-052519
Rickman, H. M.; Rampling, T.; Shaw, K.; Martinez-Garcia, G.; Hail, L.; Coen, P.; Shahmanesh, M.; Shin, G. Y.; Nastouli, E.; Houlihan, C. F., Nosocomial transmission of COVID-19: a retrospective study of 66 hospital-acquired cases in a London teaching hospital. Clinical Infectious Diseases 2020. https://doi.org/10.1093/cid/ciaa816
Wang, X.; Ferro, E. G.; Zhou, G.; Hashimoto, D.; Bhatt, D. L., Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers. JAMA 2020. https://doi.org/10.1001/jama.2020.12897
Zhu, S.; Zong, Z., Why did so few healthcare workers in China get COVID-19 infection. QJM: An International Journal of Medicine 2020
REQUIRED INFORMATION FOR EFFECTIVE INFECTIOUS DISEASE OUTBREAK RESPONSE SARS-CoV-2 (COVID-19) Updated 1/11/2022 CLEARED FOR PUBLIC RELEASE 84
Jones, R. M., Relative contributions of transmission routes for COVID-19 among healthcare personnel providing patient care. Journal of Occupational and Environmental Hygiene 2020, 1-8. https://doi.org/10.1080/15459624.2020.1784427
WHO, Mask use in the context of COVID-19; World Health Organization: 1 December 2020, 2020. https://apps.who.int/iris/rest/bitstreams/1319378/retrieve
WHO, Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected; 2020. https://www.who.int/publications-detail/infection-prevention-and-control-duringhealth-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125
Weissman, D. N.; de Perio, M. A.; Radonovich, L. J., Jr, COVID-19 and Risks Posed to Personnel During Endotracheal Intubation. JAMA 2020. https://doi.org/10.1001/jama.2020.6627
Feldman, O.; Meir, M.; Shavit, D.; Idelman, R.; Shavit, I., Exposure to a Surrogate Measure of Contamination From Simulated Patients by Emergency Department Personnel Wearing Personal Protective Equipment. JAMA 2020. https://doi.org/10.1001/jama.2020.6633
WHO, Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases.
Klompas, M.; Baker, M.; Rhee, C., What Is an Aerosol-Generating Procedure? JAMA Surgery 2021, 156 (2), 113-114. https://doi.org/10.1001/jamasurg.2020.6643
Brosseau, L. M.; Jones, R., Commentary: Protecting health workers from airborne MERS-CoV learning from SARS. http://www.cidrap.umn.edu/news-perspective/2014/05/commentary-protectinghealth-workers-airborne-mers-cov-learning-sars.
FDA, FAQs on Shortages of Surgical Masks and Gowns. https://www.fda.gov/medicaldevices/personal-protective-equipment-infection-control/faqs-shortages-surgical-masks-andgowns#kn95.
FDA, Respirator Models Removed from Appendix A. https://www.fda.gov/media/137928/download (accessed 05/15/2020).
Zha, M.; Alsarraj, J.; Bunch, B.; Venzon, D., Impact on the fitness of N95 masks with extended use/limited reuse and dry heat decontamination. Journal of Investigative Medicine 2021, jim-2021001908. https://jim.bmj.com/content/jim/early/2021/09/07/jim-2021-001908.full.pdf
Degesys, N. F.; Wang, R. C.; Kwan, E.; Fahimi, J.; Noble, J. A.; Raven, M. C., Correlation Between N95 Extended Use and Reuse and Fit Failure in an Emergency Department. JAMA 2020. https://doi.org/10.1001/jama.2020.9843
Byambasuren, O.; Beller, E.; Clark, J.; Collignon, P.; Glasziou, P., The effect of eye protection on SARS-CoV-2 transmission: a systematic review. Antimicrobial Resistance & Infection Control 2021, 10 (1), 156. https://doi.org/10.1186/s13756-021-01025-3
Cheng, Y.; Ma, N.; Witt, C.; Rapp, S.; Wild, P. S.; Andreae, M. O.; Pöschl, U.; Su, H., Face masks effectively limit the probability of SARS-CoV-2 transmission. Science 2021, eabg6296. https://science.sciencemag.org/content/sci/early/2021/05/19/science.abg6296.full.pdf
Fawcett, S. E.; Madhusudhan, M. S.; Gaddam, E. N.; Almario, M. J.; Masih, S. R.; Klute-Evans, D. D.; Johnson, J. C.; Stroud, C. D.; Dolan-Caren, J. A.; Ben-Aderet, M. A.; Luria, J.; Morgan, M. A.; Vail, E.; Grein, J. D., Transmission risk of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) to healthcare personnel following unanticipated exposure to aerosol-generating procedures: Experience from epidemiologic investigations at an academic medical center. Infection Control & Hospital Epidemiology 2021, 1-3. https://www.cambridge.org/core/article/transmission-risk-of-severe-acute-respiratorycoronavirus-virus-2-sarscov2-to-healthcare-personnel-following-unanticipated-exposure-toaerosolgenerating-procedures-experience-from-epidemiologic-investigations-at-an-academic-medicalcenter/92D47486DDC498C57B9BE9B38588FF0A
Masks for Prevention of Respiratory Virus Infections, Including SARS-CoV-2, in Health Care and Community Settings. Annals of Internal Medicine 0 (0), null. https://www.acpjournals.org/doi/abs/10.7326/M20-3213
6b. Vaccination (Prevention)
6b1. the Vaccines
6b1.1 Vaccination and LT COVID
6b1.2 Breakthrough COVID and LTC
6b2. the Vaccine Concerns
6c. Research
6c1. Funding Research